STEPdb: Sub-cellular Topologies of E.coli Polypeptides.

View: Proteins with multiple sub-cellular topologies in E.coli K-12 (MG1655)  Export to Excel  Export to CSV  

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Proteins with multiple sub-cellular topologies in E.coli K-12 (MG1655)

Bacterial cell cartoon of sub-cellular locations


Protein ID
(Uniprot)
Accession
(Uniprot)
Gene Name
(Uniprot)
Order
Locus Name
Protein Name
(Uniprot)
Full Name
Symbol
Uniprot
EchoLOCATION
Extracellular Appendage
First Level
Targeting
Chaperoning
First Level
Secretion
System
Second Level
Targeting
Chaperoning
Second Level
Secretion
System
K-12 Core
Proteome
(yes/no)
K-12 Basic
Proteome
(yes/no)
RPOD_ECOLI
P00579
rpoD

alt

b3067 JW3039
RNA polymerase sigma factor rpoD (Sigma-70)
Nucleoid, Peripheral inner membrane protein facing the cytoplasm
N, F1
N/A
 
Cytoplasmic
 
TF
 
 
 
yes
yes
SYA_ECOLI
P00957
alaS

lovB

b2697 JW2667
Alanyl-tRNA synthetase (EC 6.1.1.7) (Alanine--tRNA ligase) (AlaRS)
Nucleoid, Peripheral inner membrane protein facing the cytoplasm
N, F1
N/A
Cytoplasm
Cytoplasmic
 
TF
 
 
 
no
yes
DNAA_ECOLI
P03004
dnaA
b3702 JW3679
Chromosomal replication initiator protein dnaA
Nucleoid, Peripheral inner membrane protein facing the cytoplasm
N, F1
N/A
Cytoplasm
Cytoplasmic
 
 
 
 
 
no
yes
BIRA_ECOLI
P06709
birA

bioR dhbB

b3973 JW3941
Bifunctional protein BirA [Includes: Biotin operon repressor; Biotin--[acetyl-CoA-carboxylase] synthetase (EC 6.3.4.15) (Biotin--protein ligase)]. Deletion of BioR resulted in a 15-fold increase of bio operon transcription in the presence of high biotin levels.
Nucleoid, Integral Inner Membrane
N, B
IM (predicted)
 
Cytoplasmic
 
SRP
SEC
 
 
yes
yes
MALT_ECOLI
P06993
malT

malA

b3418 JW3381
HTH-type transcriptional regulator MalT
Nucleoid, Peripheral inner membrane protein facing the cytoplasm
N, F1
N/A
 
Cytoplasmic
 
TF
 
 
 
yes
yes
PUTA_ECOLI
P09546
putA

poaA

b1014 JW0999
Bifunctional protein putA [Includes: Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase); Delta-1-pyrroline-5-carboxylate dehydrogenase (P5C dehydrogenase) (EC 1.5.1.12)]
Nucleoid, Peripheral inner membrane protein facing the cytoplasm
N, F1
Soluble IM Fraction
 
Cytoplasmic
 
 
 
 
 
yes
yes
ENO_ECOLI
P0A6P9
eno
b2779 JW2750
Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase)
Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm, Peripheral outer membrane protein facing the extra-cellular space
A, F1, F4
Soluble IM Fraction
Cytoplasm -> cytoskeleton | Secreted | Cell surface
Cytoplasmic (Experimental)
 
 
Uknown mechanism
 
 
yes
yes
FIS_ECOLI
P0A6R3
fis
b3261 JW3229
DNA-binding protein fis (Factor-for-inversion stimulation protein) (Hin recombinational enhancer-binding protein)
Nucleoid, Peripheral inner membrane protein facing the cytoplasm
N, F1
N/A
 
Cytoplasmic
 
 
 
 
 
yes
yes
IHFA_ECOLI
P0A6X7
ihfA

hid himA

b1712 JW1702
Integration host factor subunit alpha (IHF-alpha)
Nucleoid, Peripheral inner membrane protein facing the cytoplasm
N, F1
N/A
 
Cytoplasmic
 
 
 
 
 
no
yes
IHFB_ECOLI
P0A6Y1
ihfB

himD hip

b0912 JW0895
Integration host factor subunit beta (IHF-beta)
Nucleoid, Peripheral inner membrane protein facing the cytoplasm
N, F1
N/A
 
Cytoplasmic
 
 
 
 
 
no
yes
RPPH_ECOLI
P0A776
rppH

nudH ygdP

b2830 JW2798
RNA pyrophosphohydrolase (EC 3.6.1.-) ((Di)nucleoside polyphosphate hydrolase) (Ap5A pyrophosphatase)
Nucleoid, Peripheral inner membrane protein facing the cytoplasm
N, F1
N/A
 
Cytoplasmic
 
 
 
 
 
yes
yes
RECF_ECOLI
P0A7H0
recF

uvrF

b3700 JW3677
DNA replication and repair protein recF
Nucleoid, Peripheral inner membrane protein facing the cytoplasm
N, F1
Soluble IM Fraction
Cytoplasm
Cytoplasmic
 
 
 
 
 
yes
yes
RNC_ECOLI
P0A7Y0
rnc
b2567 JW2551
Ribonuclease 3 (EC 3.1.26.3) (Ribonuclease III) (RNase III)
Nucleoid, Peripheral inner membrane protein facing the cytoplasm
N, F1
N/A
Cytoplasm
Cytoplasmic
 
TF
 
 
 
yes
yes
RHLB_ECOLI
P0A8J8
rhlB

mmrA

b3780 JW3753
ATP-dependent RNA helicase rhlB (EC 3.6.4.13)
Nucleoid, Peripheral inner membrane protein facing the cytoplasm
N, F1
N/A
 
Cytoplasmic
 
 
 
 
 
yes
yes
RRAA_ECOLI
P0A8R0
rraA

menG yiiV

b3929 JW3900
Regulator of ribonuclease activity A
Nucleoid, Peripheral inner membrane protein facing the cytoplasm
N, F1
N/A
 
Cytoplasmic
 
 
 
 
 
no
yes
WZA_ECOLI
P0A930
wza
b2062 JW2047
Putative polysaccharide export protein wza
Outer Membrane Lipoprotein, Peripheral outer membrane protein facing the extra-cellular space
I, F4
N/A
Cell outer membrane | Multi-pass membrane protein
Outer membrane Lipoprotein (Experimental)
 
 
SEC
 
LOL
yes
yes
CYSB_ECOLI
P0A9F3
cysB
b1275 JW1267
HTH-type transcriptional regulator cysB (Cys regulon transcriptional activator)
Nucleoid, Peripheral inner membrane protein facing the cytoplasm
N, F1
IM (predicted)
Cytoplasm
Cytoplasmic
 
 
 
 
 
yes
yes
ARCA_ECOLI
P0A9Q1
arcA

cpxC dye fexA msp seg sfrA

b4401 JW4364
Aerobic respiration control protein ArcA (Dye resistance protein)
Nucleoid, Peripheral inner membrane protein facing the cytoplasm
N, F1
N/A
Cytoplasm
Cytoplasmic
 
 
 
 
 
yes
yes
OMPR_ECOLI
P0AA16
ompR

kmt ompB

b3405 JW3368
Transcriptional regulatory protein ompR
Nucleoid, Peripheral inner membrane protein facing the cytoplasm
N, F1
Soluble IM Fraction
Cytoplasm
Cytoplasmic
 
 
 
 
 
yes
yes
ARCD_ECOLI
P0AAE5
ydgI
b1605 JW1597
Putative arginine/ornithine antiporter
Nucleoid, Integral Inner Membrane
N, B
IM (predicted)
Cell inner membrane | Multi-pass membrane protein.
Integral Membrane Protein (Experimental)
 
SRP
SEC
 
 
yes
yes
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